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NSF closes fiscal 2026 with over $1 billion left unspent

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Over $1 billion sat unused in US National Science Foundation (NSF) accounts as fiscal 2026 came to a close Oct. 1. A White House Office of Management and Budget apportionment published in August estimates that the NSF will carry $1.7 billion over into fiscal 2027.

The exact number will probably keep changing for at least another year and a half as the agency consolidates and reevaluates figures coming from its different accounts, says Alessandra Zimmermann, project director for the R&D budget and policy program at the American Association for the Advancement of Science. The New York Times recently reported a number closer to $1.4 billion.

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Common Chemicals Trigger Alarming Changes in Human Breast Tissue Models

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Artificially Colored Breast Tissue OrganoidA breast tissue organoid that has been artificially colored. Credit: The Kuperwasser Lab

Chemicals that disrupt hormones may leave a molecular “scar” that could someday help identify people at higher risk of breast cancer, research in human breast tissue models suggests.

People are typically exposed to several chemicals at once, including endocrine-disrupting chemicals that can interfere with the body’s hormones. Scientists have increasingly questioned whether these exposures contribute to breast cancer risk. Much of the evidence, however, comes from animal models or laboratory-grown cells that cannot fully reproduce the complexity of human breast tissue.

Researchers at Tufts University School of Medicine and Boston University investigated those effects using three-dimensional models of normal human breast tissue called organoids. Their study, published in the Proceedings of the National Academy of Sciences, found that three common bisphenols, BPA, BPS, and BPF, produced relatively few changes when tested individually. When combined at very low concentrations comparable to levels detected in human blood and urine, the chemicals disrupted normal development in organoids from most of the tissue donors.

Breast development continues long after birth

The organoids were grown from breast tissue donated by 13 healthy young women. They contain multiple types of breast cells and can reproduce some aspects of human breast tissue development, allowing researchers to examine chemical exposures during that process.

“The breast also is unusual in that it undergoes major developmental changes well after birth, including during puberty and pregnancy,” said Charlotte Kuperwasser, the study’s senior author and a professor of developmental, molecular, and chemical biology at Tufts University School of Medicine. “And the concern is that breast tissue cells may be highly sensitive to environmental cues, such as chemical exposure, during critical windows of mammary gland development.”

As the organoids developed over about three weeks, the team exposed them to individual chemicals and mixtures. The panel included substances that disrupt hormones, chemicals that affect metabolism, and known or suspected carcinogens. Researchers then analyzed changes in gene activity and DNA modifications. Different chemicals affected development in different ways, with the bisphenol mixture producing the most striking finding.

“We intentionally used concentrations of chemicals that were relevant to real-world exposure rather than the very high doses sometimes used in toxicology studies,” said Kuperwasser. “We also tested a mixture of these because people are typically exposed to multiple chemicals at the same time.”

A molecular resemblance to lobular cancer

To explore how the changes associated with the bisphenol mixture might relate to disease, the team compared them with molecular data from human breast cancers. The exposure-associated pattern was most strongly represented in data from patients with invasive lobular carcinoma, a type of breast cancer that may not produce a detectable lump and can be difficult to detect with a mammogram.

That resemblance does not establish that the chemicals cause cancer or explain how the observed changes might contribute to breast disease. The researchers instead describe the work as a new way to investigate how environmental exposures affect normal human tissue before cancer develops.

“Historically, we have thought about cancer risk largely in terms of inherited mutations, lifestyle factors, and exposures that directly damage DNA,” said Kuperwasser. “These findings raise another possibility: Environmental exposures may subtly alter how normal tissues develop, leaving behind molecular changes that do not cause cancer by themselves but may make the tissue more permissive to cancer many years later.”

Molecular “scars” might guide earlier screening

Kuperwasser noted that persistent molecular changes could eventually serve as a biological record, like a “scar” of past exposure. If validated in people, such markers could potentially help identify individuals at higher risk of breast cancer and guide earlier or more targeted screening.

“If these results are validated by additional studies, they could change how we think about cancer prevention,” said Kuperwasser.

Studies involving larger and more diverse groups of donors, along with a broader range of chemicals and mixtures, are needed to determine how widely the findings apply. Researchers also need to establish whether the molecular changes seen in organoids persist in human tissues and whether they are associated with, or contribute to, breast disease later in life.

Reference: “Environmental chemical mixtures reprogram mammary epithelial development to epigenetic states associated with breast cancer” by Meadow Parrish, Meloryn Seraj, Helia Nikoueian, Nicole Traugh, Andrew Chen, Piyush B. Gupta, Stefano Monti and Charlotte Kuperwasser, 15 October 2026, Proceedings of the National Academy of Sciences.
DOI: 10.1073/pnas.2613054123

Supported by Find The Cause Breast Cancer Foundation.

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On legacy ideas - Chris Dillow

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A lot has been written about how the right has been radicalised in recent years. Among civilised people, however, there is the opposite problem - that their beliefs have not sufficiently changed with the times.

Napoleon never actually said “to understand the man you have to know what was happening in the world when he was twenty”, but if he had he would have been right. Our formative years are, well, formative. People who grew up in hard times (pdf) are more risk-averse in later life and even more introverted and emotionally unstable. It’s plausible therefore that ideas we acquire in our formative years might persist decades later, even outliving their empirical base.

One example of what I mean is Labour’s desire to create good jobs. This is wholly understandable; anyone over the age of 40 would have been formed by experience of mass unemployment, when job creation should have been the top priority. But things aren’t so simple today. We’re not far from what is effectively full employment; there’ll always be some jobless because of mismatches between the characteristics of the unemployed and those required by employers. In this world, significant job creation would lead to higher wage inflation, to which the Bank of England would respond with higher interest rates. (The same of course would be true of significant increases in military spending.)

For now, at least, therefore, our problem isn’t simply to create good jobs. It’s to destroy some others to make room for the ones we want: builders, solar panel makers, heat pump installers, drone manufacturers, carers and so on.

You might imagine that this is the function of macroeconomic policy; higher taxes or higher interest rates do indeed destroy jobs.

Problem is, they’re not necessarily the ones we want to destroy. Such measures would tend to depress consumer spending and hence risk exacerbating the decline of our high streets. Not only is this a bad thing in itself, it would tend to strengthen the far right.

Here we run into another idea from our youths that is no longer useful. Maynard Keynes wrote:

I see no reason to suppose that the existing system seriously misemploys the factors of production which are in use...It is in determining the volume, not the direction, of actual employment that the existing system has broken down.

This, however, is no longer true. Factors of production are misemployed. We have “genuinely unskilled” fund managers exploiting clients; young Deliveroo riders jeopardising pedestrians; bullshit jobs; surveillance and guard labour; and well-paid lawyers and accountants helping people dodge tax. Higher taxes or interest rates on their own won’t destroy these jobs. We need other, more interventionist, policies. But decades of that Keynesian mindset don’t prepare us for thinking about these.

This is not the only way in which faith in free markets is a legacy idea that’s no longer so relevant today. Most of us over the age of 40 were educated to take decent economic growth for granted; in the 60 years after WWII real GDP grew by an average of 2.3% a year.

Such dynamism led politicians to believe that the task of government was mostly to create the conditions in which capitalism could get on with the job of delivering the goods. On the Tory side, these comprised weaker trades unions, privatization, tax cuts and government otherwise stepping aside; on the Labour side policy stability and education. Both, though, took for granted an underlying dynamism. But that has disappeared, and might in fact have been only an artefact of the post-war years. Our challenge now is either to find new ways of raising growth (which requires an attack on powerful vested interests) or to find ways of living with stagnation. The political elites seem unable to do either.

Yet another outdated legacy idea is our attitude to markets. Those of us formed during the cold war and its aftermath were inculcated into a simple ideological dichotomy: free markets vs central planning. The upshot is that we’re ill-equipped to think of the market as a technology - something that’s more useful in some contexts than others, and which needs adapting to conditions.

Ronald Coase famously pointed out that there is “a cost of using the price mechanism”. This can be the cognitive load of finding the best products or jobs; the difficulty of minimizing how much one is ripped off by utility and broadband suppliers; time spent shopping around; the difficulty of enforcing or escaping contracts; and so on. Companies have evolved ways of reducing this cost. For individuals, however, this evolution has been less developed. We know that state regulation is inadequate, but could we not develop stronger consumer advisors and advocates to both help us in markets and be a countervailing power to that of big companies? Again, the legacy of an ideologized state vs market dichotomy holds us back from more rigorous thinking that can address the problems of rip-off Britain.

There’s another damaging legacy idea: our attitudes to the media. Years ago, millions of people bought newspapers: in 1992, for example, the combined sales of the Sun, Mail, Express and Telegraph were 7.8m a day. That meant governments had to pay attention to the newspapers not only because they reached so many voters but also because they expressed the opinion of those voters. Today, however, these four sell only around 1.5m (we can’t be exact because the Telegraph and Sun no longer publicise their sales). That represents less than one voter in 30, and I suspect many of these buyers are fixed in their voting intentions.

During my adulthood, the press has gone from mainstream to marginal. And yet it still dominates politics not merely because MPs court its favour but because it sets the agenda, even on the BBC. The upshot is that politics is dominated by culture war BS and attacks on migrants, trans people and scroungers to the detriment of issues that affect our everyday lives such as stagnating living standards, rip-off utility bills, high street decline, climate change, poor public services and so on.

This dominance, however, is a legacy idea. It was formed when the press was influential and persists beyond its evidence base. But the fact is that newspapers represent a small, cranky and racist minority; many more people today own a fishing licence than buy the Daily Mail on a typical day. Their power is like that of the Wizard of Oz’s; it exists only because people believe in it, and behind the curtain is a mere humbug.

Recognizing that our ideas about the media are out-dated is, however, only part of the story. The questions then arise: is it possible to rebuild our public sphere so as to permit rational informed debate? Can we overcome the problems posed by fragmentation, cranks and fanatics? Again, old ideas are no use to us.

I don’t intend all this as a complete list of zombie ideas; I’d add the idea of bankers’ bonuses to that. I do so merely to show that the ideas that people over the age of around 50 formed in their youth are a handicap to thinking about politics today. Modernization has a bad rap these days, partly because it is tainted by association with Blairism, but it is just what we need now.

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Do any of these Israeli candidates support a Palestinian state? | News | Al Jazeera

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Do any of these Israeli candidates support a Palestinian state?

What do these eight representatives from different Israeli parties competing in the upcoming election agree on? They all reject the establishment of a Palestinian state.

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  • Britain's Conservative Party leader Kemi Badenoch delivers her keynote speech on the final day of the Conservative Party conference in Birmingham, Britain, October 7, 2026. REUTERS
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