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It’s hard to see how all the social structures that support Friday linkfests will avoid major disruption over the next few years

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This week: 2026 ASN award winners announced, ChatGPT vs. mathematics, the single most important rigor-enhancing practice in all of science, and more.

Congratulations to the 2026 ASN award winners!

The registration deadline for the 11th evolutionary demography conference June 18-26 has been extended until June 1. I don’t work on the ecology and evolution of structured populations myself, or on human demography. But I have friends who do, and they all love this conference. So if you work on those things, I encourage you to look into attending.

“The most important ‘rigor-enhancing practice’ is caring about getting things right, and without that nothing else matters.” Adam Mastroianni brings the heat. Wow. I covered some of the same ground in this recent post, but not like this. That brief quote doesn’t really do the post justice.

I’m late to this, but here are proposed updates to the regulations of the Canadian Panel on Responsible Conduct of Research. These regulations govern how researchers who receive TriCouncil research funding, and the universities employing those researchers, are supposed to respond to allegations of scientific misconduct. One proposal is that there’d be no statute of limitations on allegations. Another is that institutions would be obliged to investigate and hold accountable respondents who are no longer affiliated with the institution. A third is that institutions would be free to consider anonymous allegations, and allegations “in the public domain” , so long as sufficient information is provided (think of PubPeer comments). A fourth is that institutions would be obliged to define retaliation against good-faith accusations (e.g., suing an accuser, or spreading malicious rumors about an accuser) as a form of misconduct. If implemented, I don’t know that these proposals are going to change anything all that much. Offhand, these seem broadly like good ideas to me, though I’d agree with Adam Mastroianni that the rules matter less than having good people to implement and enforce them.

This week in unsurprising results: a new preprint finds that people prefer interacting with sycophantic LLM chatbots that validate their beliefs. Chatbot users also rated sycophantic chatbots as more unbiased. And the only way for the chatbots to get users to take on board information that contradicted their pre-existing beliefs was to present that information as validating the user’s other beliefs. I’m not too worried about this (though what do I know, obviously), because hasn’t it ever been thus? I mean, it’s not as if lots of people wanted to be contradicted back in the pre-LLM days. And it’s not as if people don’t already have lots of ways to avoid having their beliefs contradicted.

Recently I linked to news that off-the-shelf ChatGPT had proven an open, and fairly well-known, conjecture in mathematics, despite not being specifically trained or tailored to do mathematics. Further, it had done so using a method of proof that impressed human mathematicians–it would’ve been called “creative” and “insightful” if a human mathematician had done it. Finally, the proof had not been memorized from the training data (i.e. the proof wasn’t already published in some obscure venue that was in the training data but that human mathematicians didn’t know about). Well, now ChatGPT has done it again, and this time it’s done it for one of the central conjectures in discrete geometry (!) It’s a very famous conjecture that was posed by the Paul Erdős in 1946. Literally every expert in discrete geometry has tried and failed to either prove it or refute it at some point. No less than Fields Medalist Timothy Gowers says that we’re now at the point where mathematicians are going to have to fundamentally rethink how they go about their work, individually and collectively.* (UPDATE: Here are some very interesting comments from a mathematician on why ChatGPT could come up with these proofs while humans couldn’t. That’s excerpted from this longer preprint with comments from a number of mathematicians. Very very interesting throughout.)

Still true. Heartbreaking that it’s less true than it once was, because the Trump administration is trying to make it not true at all. But still true.

*Aside: some of the reactions to Timothy Gowers’ Bluesky post about the proof are a good illustration of the link in the previous paragraph. People who hate AI for whatever reason really don’t like hearing that AI is ever useful for anything, and so will reach for any excuse to deny that AI is ever useful. You might think that “AI is genuinely useful for some purposes,” and “AI is a bad thing for the world on balance” would be easy thoughts to hold in your head at once, especially when you’ve just been told that AI is genuinely useful for mathematics by literally one of the world’s greatest mathematicians. But apparently not, at least not for the sort of people who talk about AI on Bluesky. Apparently, Bad Things must be Bad always and everywhere, otherwise they’re not truly Bad, I guess? Maybe Timothy Gowers should’ve found a way to spin this proof as somehow confirming something else that AI haters on Bluesky believe (“Here’s why this proof shows that Elon Musk is terrible.”)**

**Aside to the aside: obviously that aside is far from the most important or interesting thing in the world! What can I say? Like many people who write words on websites, nothing annoys me quite like (some) other people who write words on websites. Consider this your invitation, if one were needed, to tell me how annoying I am sometimes.



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sarcozona
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“You might think that “AI is genuinely useful for some purposes,” and “AI is a bad thing for the world on balance” would be easy thoughts to hold in your head at once, especially when you’ve just been told that AI is genuinely useful for mathematics by literally one of the world’s greatest mathematicians. But apparently not”
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Nocebo effects with antidepressant clinical drug trial placebos - PubMed

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We describe an individual who experienced unusual negative effects while taking a placebo during a clinical drug trial. A 26-year-old male took 29 inert capsules, believing he was overdosing on an antidepressant. Subsequently, he experienced hypotension requiring intravenous fluids to maintain an adequate blood pressure until the true nature of the capsules was revealed. The adverse symptoms then rapidly abated. The nocebo effect (undesirable symptoms following administration of an inert substance that the patient believes to be an active drug) may have significant negative impacts on certain patients. Further research is warranted to better understand this phenomenon.

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LeAnn Rimes reveals her struggles with difficult health issue in candid statement about 'heartbreak'

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Jessica Simpson has defended herself after her ex-husband, Nick Lachey, revealed that she flew first class to Hawaii while her three kids sat in coach.

Nick recalled his unexpected run-in with Jessica during a recent appearance on Watch What Happens Live with Andy Cohen, revealing that both their families were on the same flight, marking the first time they had seen each other in 20 years since their divorce.

During the chat, Nick said that Jessica sat in first class, while her children, Maxwell, 14, Ace, 12, and Birdie, seven, flew in a "separate class of service" with their dad, Eric Johnson.

Jessica has now set the record straight, revealing that she had nothing to do with the seating arrangements.

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  1. Newlyweds Turns 20: What have Jessica Simpson and Nick Lachey said about each other?

"My mom bought those tickets. It was my mom's treat for us to go to Hawaii," she said, according to Page Six.

Jessica insisted that if she had bought the tickets, "of course," her children would be seated with her.

Eric Johnson, Jessica Simpson, Birdie Mae Johnson, Ace Knute Johnson and Maxwell Drew Johnson pose at Barnes &amp; Noble Union Square

Nick revealed Jessica sat in first class away from her 3 kids and estranged husband, Eric (Getty Images)

Nick and Jessica were married from 2002 to 2006, and fans saw their marriage deteriorate on their reality show Newlyweds: Nick and Jessica, which ran for two seasons.

Recalling the experience of finding Jessica on the same flight, Nick said it was "strangely okay." He explained: "You know it's been 20 years … and so we haven't seen each other in those 20 years and then spent six and a half hours on a flight to Hawai'i together."

Nick Lachey and Jessica Simpson during Gucci Spring 2006 Fashion Show to Benefit Children&#39;s Action Network and Westside Children&#39;s Center - Arrivals at Home of Eva and Michael Chow in Beverly Hills, California, United States

Jessica and Nick were on the same flight to Hawaii (WireImage)

He then clarified that by "spent" he meant they were simply in the "same vicinity," though emphasized: "Everyone was very very cordial, very respectful."

He further shared that his whole family was on the flight; Nick has been married to Vanessa Lachey since 2011, and they are parents to son Camden, 13, daughter Brooklyn, 11, and son Phoenix, nine.

DAILY POP -- Episode 190429 -- Nick and Vanessa Lachey pose for a photo on set

Nick is now married to Vanessa Lachey (Getty Images)

Jessica, meanwhile, announced her separation from Eric in January 2025 after 10 years of marriage.

The singer, actress, and business mogul confirmed the heartbreaking news in a statement to People, sharing that she and her former NFL player husband had been living apart for some time.

"Eric and I have been living separately, navigating a painful situation in our marriage," Jessica revealed at the time.

Jessica Simpson in white dress and trench and Eric Johnson in blue shirt and red cap

Jessica Simpson and Eric Johnson split in January 2025 (Getty Images)

"Our children come first, and we are focusing on what is best for them. We are grateful for all of the love and support that has been coming our way, and appreciate privacy right now as we work through this as a family."

The former couple has yet to finalize their divorce and appear to be on amicable terms. Last year, after Jessica and Eric spent Thanksgiving together with their kids, the former gave insight into how co-parenting was working for them.

Jessica Simpson poses with Eric Johnson, Birdie Mae Johnson, Ace Knute Johnson and Maxwell Drew on February 05, 2020 in New York City

Jessica and Eric are still on good terms (Getty Images)

Speaking with TMZ at the airport, she said that "of course" they would celebrate the holiday together, maintaining: "It's my kids' father."

It was reported last month that Jessica is dating Nashville-based musician Thomas Eisenhood.

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Promising hantavirus vaccine research stalled by funding gap before outbreak

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Promising early results have been put on the back burner despite renewed global concern following a deadly cruise ship outbreak.

Follow us on GoogleMedics work outside of the cruise ship MV Hondius, which was affected by a hantavirus outbreak, after it arrived at the Port of Rotterdam, where Dutch authorities are preparing quarantine arrangements, in Rotterdam, Netherlands, May 18, 2026.Medics work outside of the cruise ship MV Hondius, which was affected by a hantavirus outbreak, after it arrived at the Port of Rotterdam, where Dutch authorities are preparing quarantine arrangements, in Rotterdam, Netherlands, May 18, 2026.(photo credit: YVES HERMAN/REUTERS)ByASHER SMITH

Scientists developing a potential vaccine for hantavirus halted key research efforts after running out of funding during trials in 2016, despite promising early results and amid renewed global concern following a deadly outbreak linked to a cruise ship in South America, according to a recent Bloomberg report.

The report came in the wake of increased attention on hantavirus after the World Health Organization (WHO) confirmed multiple infections and at least three deaths connected to an outbreak involving the Andes strain of the virus aboard the MV Hondius cruise ship, which left Argentina on April 1. 

Unlike most hantaviruses, which spread through contact with infected rodents, the Andes variant can spread from person to person, raising concerns among infectious disease experts about broader transmission risks, according to the WHO.

María Inés Barría, a virologist and researcher at Universidad San Sebastián in Chile, developed antibodies to treat hantavirus and successfully neutralized it in 2016.

After successful animal testing, the lab was ready to begin testing on human subjects when they ran out of money and had to end their research prematurely.

The body of a German woman who died is disembarked from the cruise ship MV Hondius, which was affected by a hantavirus outbreak, after the ship arrived at the Port of Rotterdam, where Dutch authorities are preparing quarantine arrangements, in Rotterdam, Netherlands, May 18, 2026.The body of a German woman who died is disembarked from the cruise ship MV Hondius, which was affected by a hantavirus outbreak, after the ship arrived at the Port of Rotterdam, where Dutch authorities are preparing quarantine arrangements, in Rotterdam, Netherlands, May 18, 2026. (credit: PIROSCHKA VAN DE WOUW/REUTERS)

Hantavirus outbreak renews global interest in combating the virus

Global attention has peaked with the discovery of an outbreak of the Andes strain of hantavirus on a cruise ship, and the need for vaccines and effective antibodies has risen.

Kartik Chandran, a professor at the Albert Einstein College of Medicine, has been incrementally developing a vaccine and an antibody treatment. The research Chandran is conducting on the virus is in its early stages, but results have shown effectiveness in protecting against the Andes strain in early trials.

Chandran told Bloomberg that the results indicate they are ready to move on to testing in humans.

“We are engaged in a number of conversations with various parties,” he said. “The goal would be to have something available should there be another outbreak. I’m optimistic that we’ll learn from the current situation and be positioned for hantaviruses down the road.”

However, with so few cases of hantavirus, conducting clinical trials in humans would be difficult for researchers, Chandran told Bloomberg

The race to develop vaccines

The race to develop a vaccine is more intense back in Chile, where there have been 39 confirmed infections and at least 13 deaths, according to the Chilean Health Ministry.

The source of the outbreak on the MV Hondius cruise ship that departed from Argentina remains a mystery. However, before headlines began reporting on the viral outbreak aboard a cruise ship, Chile was already laying the groundwork to develop a vaccine, but funding dried up, and the global COVID-19 crisis diverted resources.

The virus had gone largely overlooked outside southern Chile in part because it is rare and geographically concentrated, Barría said. “It has always been a public health problem here, but without a solution,” she added.

As the outbreak on the cruise ship draws global attention, the race to develop a vaccine has been restarted, but Barría has said the researchers need funding and time.

“The key factor that’s preventing further progress is funding and resources,” she told Bloomberg.

“We have made significant advances, but we’ve reached a stage that is much more expensive and requires a different level of investment, as well as specific infrastructure that we are currently lacking.”

On top of the need for funding, Barría also estimated that her team at Universidad San Sebastián in Chile would need one to two years to return to the place they were before the Covid-19 pandemic and funding troubles interrupted their research.

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WHO delays pandemic treaty amid pathogen-sharing dispute | Reuters

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U of C student living with POTS leads new study on long-term impacts of chronic condition | CBC News

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A Calgary student is drawing from lived experience with a neurological disorder to further the medical field's understanding of it.

University of Calgary medical student Kate Bourne is the lead author of a new study on long-term care outcomes of patients with postural orthostatic tachycardia syndrome (POTS), a chronic condition she was diagnosed with at 24.

POTS, a disorder of the nervous system that primarily affects women of childbearing age, causes symptoms such as rapid heartbeat, dizziness, fatigue and nausea when standing up.

The study, which involved 44 patients diagnosed over 20 years ago, suggests that while POTS did not disappear in the vast majority of long-term patients, almost half had their symptoms improve through treatment, time or a combination of both.

The University of Calgary estimates the condition affects up to 450,000 Canadians.

University of Calgary student and study lead author Kate Bourne was diagnosed with postural orthostatic tachycardia syndrome at 24, after first displaying symptoms over a decade beforehand. Now, at 36 years old, Bourne is looking to dedicate her career as a doctor and researcher to studying the condition. (Kristen Fong/Cumming School of Medicine)

POTS is a subject Bourne is all too familiar with.

"It actually took me 12 years to get a diagnosis of POTS," said Bourne.

She says she first became sick at 12 years old, experiencing gastrointestinal symptoms and fatigue that doctors struggled to explain.

"I was a very active child," she said. "I played lots of sports, horseback riding, music, and then all of a sudden I couldn't get out of bed."

The persistent unexplained symptoms forced her to do an extra year of high school and take eight years to complete her undergraduate degree, she said.

Now, at 36 years old, Bourne's symptoms are well controlled with available treatments. While she still has bad days, she's got a good hold on managing her condition.

"My career goal is actually to be a doctor and researcher studying POTS, so that hopefully other young women and girls don't have to experience the challenges that I've experienced," she said.

Rashmin Hira, left, takes part in research with Kate Bourne. (Kristen Fong/Cumming School of Medicine)

"It definitely helps me relate to research participants," Bourne said on being a POTS patient herself.

"Oftentimes they'll tell me that I'm the first person they've ever met who has POTS, and that helps to build the relationship in the research setting."

Study lead Dr. Satish Raj, a professor with the university's department of cardiac sciences, said the new findings offer a better understanding of the long-term outcomes for POTS patients.

"For most patients, it doesn't go away," he said. "Only two per cent of the patients reported that the symptoms totally resolved. That's the bad news. The good news is that for almost half the patients, they report that over time their symptoms improved."

Raj said this offers hope that interventions can lead to better functioning, even if not a complete return to normalcy.

"I think this is important news for patients, but also for physicians to say this is actually something that is serious and we're going to need to treat," Raj said.

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