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Fourth dead after infection with West Nile virus, patient infected by blood transfusion

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Het Rijksinstituut voor Volksgezondheid en Milieu (RIVM) meldt dat er in Nederland een vierde dode is gevallen na besmetting met het westnijlvirus. Het gaat om een persoon die al ziek was en besmet raakte door een bloedtransfusie.

Volgens het RIVM is het niet duidelijk of het slachtoffer daadwerkelijk is overleden aan de gevolgen van het virus. Mogelijk was diens kwetsbare gezondheid de oorzaak van het overlijden.

De donor was iemand die ook besmet was met het virus, maar dat was op het moment van donatie nog niet bekend. Toen de bloeddonor positief testte op het virus, heeft bloedbank Sanquin dit bloed geblokkeerd, meldt persbureau ANP. Daardoor zou niemand anders dan het overleden slachtoffer het hebben ontvangen.

Het RIVM meldt daarnaast dat bij tien andere patiënten het westnijlvirus is vastgesteld. Het aantal vastgestelde besmettingen is daarmee in een week gestegen van 18 naar 28. Behalve de persoon die besmet raakte door een bloedtransfusie, raakte iedereen besmet door een beet van een mug.

Dit gebeurde in de provincies Utrecht, Noord-Brabant, Noord-Holland, Zuid-Holland, Overijssel en Gelderland. De besmettingen werden vastgesteld nadat de besmette personen met klachten in het ziekenhuis waren beland. Het RIVM schat in dat het aantal besmettingen in werkelijkheid veel hoger is.

Voor de meeste mensen (80 procent) is het westnijlvirus ongevaarlijk en levert het nauwelijks klachten op. Iets minder dan een op de vijf mensen krijgt griepachtige klachten zoals koorts, hoofdpijn en spierpijn. Het zijn vooral ouderen en mensen met een kwetsbare gezondheid die risico lopen.

Bij het westnijlvirus is besmetting van mens tot mens niet mogelijk. De meeste mensen lopen het virus op via muggen die zich hebben gevoed met bloed van vogels die het virus bij zich dragen.

Sinds de vorige update zijn dertig nieuwe positief geteste paarden gemeld. Daarmee komt het totaalaantal meldingen van paarden met westnijlvirus in 2026 op 88.

In totaal zijn er in 2026 nu 100 vogels met het westnijlvirus gemeld. Volgens het RIVM is vooral de hoge sterfte onder kraaiachtigen opvallend. Hoeveel kraaiachtigen zijn overleden, is niet duidelijk.

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sarcozona
30 minutes ago
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What to know about self-harm as emergency room visits increase - CalMatters

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It had been four days since Jae Janea had spoken to anyone. The loneliness was setting in. Dark thoughts were becoming overwhelming. So on a summer evening last year she walked into a dollar store and bought a pack of razor blades. 

Janea went home and cut her wrists. She thought she was ready to go. Instead she called her best friend who told her to make a tourniquet. When her friend arrived, she helped bandage Janea’s wounds. The next morning they went to urgent care. 

“It was in that moment when I realized I don’t want to be gone. I just don’t want to feel this intense pain. I was trying to find a way to make it stop,” she said.  “But it was absolutely not the appropriate way. I wish I could tell myself differently then.”

Janea struggled with self-harm for many years before her suicide attempt.  Since then, Janea has put additional measures in place so she doesn’t find herself in that situation again. Amping up her therapy sessions, eating balanced meals, engaging in physical activity, and learning to create space between herself and her emotions. 

At times, she admits, she still feels the urge to harm herself. And the 22-year-old is not alone in her feelings.

National research shows emergency room visits connected to self-harm climbed through 2021, and the numbers remain elevated above pandemic-levels in California even as other indicators of mental distress have declined. In the California 2026 State of the Girl Report, nearly a quarter of grade 7 girls report self-harm. 

In a recent UC Berkeley analysis, researchers found an increase of multiracial adolescent girls being treated for self harm injuries in California hospitals. 

Overall the number of adolescents in the state engaging in self-harm is increasing, Emily Liu, lead author of the UC Berkeley report said. With the use of inpatient and emergency department hospital discharge data from 2005 to 2021, more than 70% were girls. By 2021, rates were highest among multiracial, white, and Black girls aged 15 to 19 years old.

California policymakers have paid close attention to youth mental health during Gov. Gavin Newsom’s administration, including backing a voter-approved 2024 ballot measure that dedicated billions of dollars to building more capacity for treatment. Newsom also supported a $4.3 billion surge in funding for youth mental programs in the budget he signed in 2022. 

More recently the California Department of Public Health developed California’s Population-Based Prevention Program Final Plan with the goal of reducing suicide, self-harm, overdose, and behavioral health disparities.

But students and representatives from schools say gaps remain. Newsom vetoed bills in 2022 and in 2023 that would have further expanded youth mental health services. 

Shalini Mustala, a researcher at the Public Policy Institute of California, said at the legislative hearing that the rate of depressive symptoms and suicidality in teens has steadily risen since 2009. And hospitalizations for self harm, post COVID-19, still remain elevated.

“Ongoing evaluation of these investments will play an important role in refining strategies for effectively addressing student mental health needs,” Mustala said. 

Dr. Janis Whitlock, an emeritus research scientist at Cornell University who has studied self-injury for more than 20 years, said self-injury is a risk factor for suicide but it’s not the same thing.

Non-suicidal self-injury, often used interchangeably with self-harm, happens when someone repeatedly injures themselves to provide temporary emotional relief. The most common forms include cutting, scratching, and burning. 

Most people who self-harm do not end up in the emergency room. If an adolescent harmed themselves at school, oftentimes Whitlock explains, school protocol is to call 911 to report a suicide attempt. It’s unlikely an adolescent would voluntarily go to the hospital for self harm injuries. 

“Most of the time people who self-injure don’t want to end up in an ER,” she said. “That isn’t their goal. The goal is to feel better. The goal is to be able to function.”

Dawn L. Brown, president and CEO of EmpowHer, isn’t new to supporting teens who self-harm. The Los Angeles nonprofit works with Title 1 schools across the county and annually serves about 1,000 girls of color from low-income communities. 

Nationally, about 17% of teens report some form of self injury, but studies show an even higher risk among college students — with a range of 17-35%. Some of the top concerns girls are dealing with, Brown said, include the fear of school shootings, threats to body autonomy, immigration, and financial security. 

In the recent State of the Girl report from Girl Scouts USA, nonbinary students report the highest level of emotional distress with 61% reporting chronic sadness and more than half of grade 9 nonbinary students report self-harm. 

“So many of our girls are feeling this overwhelming sense that they are being attacked for who they are. We do have a large population of LGBTQIA+ youth,” she said. “I think that plays a big role as to why we’re seeing an increase of Black and Latina girls (self-harming) because they are being ignored and disregarded.”

There’s a strong link between self-injury and trauma. Although some studies show demographic differences in who self-injures based on ethnicity and socioeconomic status, Whitlock said the differences aren’t by a lot. Nationally, the data shows the rates of young girls self harming continue to increase.

Self-harm “absolutely is stigmatized as a white girl problem, historically it has not impacted us in the same way, but self-harm has always happened in the Black community,” Brown said. “From a cultural standpoint we tend to sweep those things under the rug, we don’t have open conversations about those things, the idea is … don’t put our business out there in the street.”

Janea describes her childhood as traumatic. As a biracial teen, she felt she didn’t always have the necessary support. Things really took a turn when she was 12. Her father tried to kill her mother and cousin. And attempted to kidnap her. He was later taken to prison.

Eight months later, at 13, she attempted suicide. 

While in the psychiatric hospital, she found it hard to be honest with her therapist. Around this time is when she started self-harming. In the years that followed, she was in and out of outpatient psychiatric care. 

But things “kept happening” in life and a strong sense of “hopelessness” was ever present. Plus she knew shutting down with her therapist wasn’t helping.

“I got sexually assaulted (at 15), that caused me to open up too because that made me feel very uncomfortable with myself,” Janea said. “Hearing those comforting and reassuring words from a therapist is what I needed to hear instead of what I was hearing from my family.”

Two years later, she was diagnosed with borderline personality disorder. Something she frequently talks about on her Instagram page with more than 200,000 followers. Janea said she made the page so others don’t feel alone and to show the world “we are more than a label.”

There’s been a lot of ups and downs in her life. Like the death of one of her best friends and then her beloved dog. The grief was “a lot.” But Janea said leaning on her village, making new friends, and continuing to seek therapy has been critical to her recovery from her suicide attempt.

“There’s been a lot of behaviors that I had to ditch that no longer serve me. Even though they once fulfilled me at a younger age, they kept me safe or they kept me sane,” she said. “Now … I don’t need to keep it in my circle anymore. Being able to learn a different coping mechanism that can help me through those same intense feelings was helpful within my healing journey.”

Too often research on self harm is grouped in with suicidality. Many clinical databases, public health surveys, and screening tools don’t separate self-harm and suicide. However, there is a clear difference between the two. 

Dr. Jill Harkavy-Friedman, senior vice president of research at the American Foundation for Suicide Prevention, said people who self harm don’t have the intent to die. If someone harms themselves with the intention to end their life that would be considered a suicide attempt, she explains. Whereas the goal with self harm is to feel relief.

Decades ago, when Whitlock started her research there wasn’t much to build off of, she said. In 2004, she founded the Cornell Research Program on Self-Injury and Recovery, to explore the then nascent phenomenon now known as non-suicidal self-injury. Although research on this topic has increased, it’s still not commensurate with research on suicidality. 

Much of the data collected on self-injury rates come from self-reported surveys or in the case of Berkely, hospital discharge data. While more data is useful, Whitlock explains, there’s other underlying reasons people who self-injure don’t seek care.

A lot of people who self-injure and seek care have bad experiences with providers. “Doctors will say, ‘I can’t believe I’m taking up time to stitch you up after you did this to yourself,’” she said. Instead, Whitlock emphasizes to the providers she works with to lead with compassion and not judge. 

In the years Janea has sought care, she said, some providers called her “drug-seeking” after trying to get pain medication from her self-inflicted injury. Other therapists were more helpful. She encourages other young Black and Latina girls who are managing self-harm to not let provider comments become a deterrent to healing. Even when life feels heavy, she said, it’s worth it to hold on.

“You can absolutely become better after everything that you’ve dealt with.” she says to young girls like herself. “I’m accepting that these bad things have happened to me, but they don’t make up who I am as a person. I can continue (to) change the trajectory of my life.”

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sarcozona
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No New Jobs Came from Alberta’s $4B ‘Job Creation’ Tax Cut for Big Oil

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Canada’s biggest oil sands companies have benefitted to the tune of $4.3 billion since Alberta handed large corporations a ‘job creation’ tax cut three years ago, but those jobs never materialized, a new study has found.

Instead, a total of 3,452 jobs with oil sands majors were lost to automation and consolidation since 2019, concludes the report from the University of Alberta’s Parkland Institute. “Meanwhile, those same companies added millions of dollars to the compensation of their CEOs and rewarded their shareholders with generous dividends,” the institute says.

Alberta Premier Jason Kenney’s United Conservative Party (UCP) government said 55,000 new jobs would be created, offsetting a projected $2.4-billion loss in revenue, from its plan to cut the corporate tax rate from 12% in 2019 to 8% by 2022. But three years later, and with the 8% tax cut delivered two years ahead of schedule via Alberta’s Recovery Plan, Parkland says that the boon to the corporate sector enriched the coffers of the oil sands “Big Four,” even as provincial revenues tanked by twice the projected amount. And 3,452 oil sands workers have been given pink slips.

“The oil sands majors have been cutting jobs on the front lines, but CEOs and shareholders have remained very well compensated,” said report author Ian Hussey, research manager at Parkland. Digging into the details, he found the CEOs of the so-called “Big Four”—Suncor Energy, Canadian Natural Resource Ltd.,, Cenovus Energy, and Imperial Oil, which account for some 86% of Canada’s oil sands production—have been enjoying an average annual pay raise of $2.35 million since the UCP corporate tax rate changed. The policy shift that left the “Big Four” alone $4.3 billion richer.

With that same amount, the government of Alberta would have had enough funds to add more than 10,000 new employees to its payroll in critical areas like health care and education, Hussey said.

The study found that shareholders have also been considerably enriched, with dividends in some cases totalling “more than twice the amount oil companies paid the province in royalties.”

In 2021, when Big Four CEOs were averaging $12.8 million annual paycheques, and the price of oil was skyrocketing, 2,988 oil workers lost their jobs, a finding that “should concern the UCP government and all Albertans,” Hussey said.

A sustained decrease in capital spending is partly responsible for the job losses, as is the fact that the oil industry has “entered the mature phase of its business life cycle,” he added.

Spending was also reduced as the Big Four navigated weak oil prices from 2015 to 2020, and now the “recent price unpredictability linked to the pandemic and to the Russian invasion of Ukraine.”

And now, despite the UCP’s tax giveaway, “no new oil sands mining megaprojects are being developed or proposed.”

Automation is also driving job losses in the oilfields themselves. Beginning in the wake of the 2014 oil price crash, the process the industry likes to call “de-manning” has intensified since the pandemic, with digitalization in field and back office operations looming large in this “troubling trend.”  

The climate emergency is also lighting a fire under oil operators determined to squeeze every dollar out of their dying industry. “Leading oil sands companies are speeding up automation to lower production costs by cutting jobs because they will soon be competing in a shrinking market, as the peak of global oil demand is likely to occur in the next five years,” Hussey said.

Citing a forecast from Ernst & Young and Petroleum Labour Market Information, he adds that automation may result in 46,108 job losses in the Canadian upstream oil and gas sector by 2040.

Amongst several recommendations, Hussey urges a return to a 12% tax rate for large corporations (the standard across British Columbia, Saskatchewan, and Manitoba) and a federal windfall profit tax “to help pay for household support programs.”

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sarcozona
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'NAZA' Review: A Devastating Exposé of Israeli Genocidal Policy

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The irksome controversy over “No Other Land” upon winning both the Berlinale Documentary prize and the Academy Award was never really about the film. It was hardly the first strong documentary to call attention to Israel’s official policy of ethnic cleansing, and there were no revelations to be had. But coming just four months after the October 7th Hamas attack, tensions were high, misinformation was rife, and Israel’s decades-long conflation of anti-Zionism and anti-Semitism had burrowed deep into the Western psyche. Simplistic media pieces marveled that Palestinian and Israeli filmmakers were working together, and film festivals claiming “not to take sides” were able to hide behind their programming and have it both ways.

The distance between then and now is saturated with the blood of more than 73,000 people, though casualty figures fail to account for the deliberate infliction of trauma on those who survive. This is the space that “NAZA” seeks to fill, and in its systematic, neutral-toned way of conveying information about Israel’s policy-driven perpetration of genocidal war crimes, it’s a more effective and urgent documentary than “No Other Land.” It also makes sense that it’s directed by only the Israeli half of that film’s directing team, Yuval Abraham and Rachel Szor, who have assumed the responsibility of revealing their government’s hidden activities in a way that would have been impossible had their fellow filmmakers joined them.

The setup is simple and remarkably effective: Over the past three years, they filmed Abraham talking to members of the Israeli military elite at night, on Tel Aviv rooftops. Each of the 24 service members is seen in obscured profile, their voices modified to make identification impossible. Asked about their duties, they describe in detail, frequently using sketchpads, how they executed their orders in Gaza. Some were involved in surveillance, several were guiding lethal drones from the safety of their Tel Aviv headquarters, and others were on the ground. All participated in erasing not just the human presence in Gaza, but the buildings themselves.

“NAZA” is the army word for “collateral damage.” Rather than talk about the murder of non-combatants, the Israeli Defense Forces (IDF) use the term “NAZA,” obviating the need to think of dead civilians as men, women and children. This erasure of human costs is not a policy that originated with Benjamin Netanyahu: For decades, the Israeli government has stocked its jails and morgues with Arab men in order to use them as bargaining chips in prisoner exchanges. Six Israelis for 291 Syrians; one dead IDF soldier for 65 prisoners and 40 bodies; one Israeli hostage for 1,027 Palestinian prisoners. The message, disseminated not just within Israel but among the diaspora, is that one Israeli, alive or dead, is worth untold numbers of Arabs.

Understanding that this is policy is crucial for comprehending how Israeli soldiers are expected to dutifully erase entire villages without questioning orders. By saying “200 NAZA” rather than “200 non-combattants killed,” the dehumanization process is handily condensed to four letters. And yet, despite being miles away from the drone attacks, the soldiers directing the strikes hear everything. The IDF listens to all Gazan phones, so they know where people are and whether children are home. They know who’s in an apartment just before the missiles hit, and they hear the screams after the explosions. They even coined a phrase — “Where’s Daddy?” — to describe listening in on a child’s phone, determining when their father will be home, and then sending a missile to kill them all. As one solider matter-of-factly says about a 12-year-old, “You hack her phone, and then you kill her.”

That’s the part most difficult to comprehend: It’s easy to use the term “NAZA” because it’s a cold statistic, but how is it possible to listen to people in agony and still accept that this is a necessary operation? “You feel like God, because you hear everything they say,” explains one of the people interviewed. In many cases, the soldiers have had Arabic training, so they can’t hide behind incomprehension, as so often happens on Western news broadcasts that show distraught Arab women but don’t bother to subtitle what they say.

The geographic distance (Gaza is a mere 37 miles from Tel Aviv) offers another form of psychological detachment, but as one IDF member says, they didn’t need psychologists — they were fully into it. Raised on video games where the more you killed the more points you got, these soldiers just transferred those dopamine highs to real life: Strikes that were successful were fun. What’s more, they’re just following orders. “My role is technical” and “You have to trust the system” are two of the familiar lines used to disguise the moral somersaults needed to perpetrate atrocities.

It’s not as if they don’t understand the ethical implications. The same man who says it was fun also openly admits to knowing Israel is committing genocide. Presumably the reason he agreed to speak with Abraham is because he feels some iota of remorse, though that concept never comes up. Someone else expresses revulsion at seeing dogs devour bodies left to rot, but the disgust doesn’t seem to extend to the killings themselves. (Conversely, the organization Breaking the Silence, composed of former soldiers actively calling attention to Israel’s policy of ethnic cleaning, was featured in Avi Mograbi’s 2021 documentary “The First 54 Years.”)

For those still unwilling to accept the word ‘genocide’ in the context of Palestine, “NAZA” makes clear that the Israeli government believes there are no innocents in Gaza, which is why snipers can so nonchalantly pick off starving people waiting at food distribution points. But genocide is not only the elimination of human lives, it’s also the deliberate destruction of property, to cover up ethnic cleansing and ensure that no one from the eliminated population will come back. Despite official Israeli denials, this too is revealed, as those involved on the ground talk about the premeditated flattening of any structure that could harbor human life.

Abraham and Szor intersperse these chilling testimonies with shots from the rooftops of the Tel Aviv skyline at night. Without seeing faces, we glimpse people in their apartments, watching TV, preparing meals, heading to sleep. The device allows the viewer a momentary space to breathe before the next wrenching description, but it also reflects on the large percentage of Israelis who also “trust the system.”

Will “NAZA” change minds, now that it’s becoming increasingly difficult to disguise what’s happening in Gaza and the West Bank? It has more of a chance than “No Other Land,” though by giving festivals claiming to be apolitical a free pass just for programming the film, we too contribute to a campaign designed to obfuscate the reality so unflinchingly revealed here.

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sarcozona
4 days ago
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Kelvin (23) is considering euthanasia, just like more and more post-covid patients: 'There is nothing left about who I once was' | EenVandaag

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Kelvin Latta (23) is een schim van de sportieve jongen die hij ooit was. "Daar is eigenlijk niks meer van over. Stuk voor stuk ben ik alles kwijtgeraakt, alles is afgebrokkeld. Nu is er eigenlijk niks meer over van wie ik ooit was."

Voor hij ziek werd had Kelvin alles: een goede baan bij de politie, net een nieuwe auto en hij sportte zes keer per week. 2,5 jaar geleden sloeg het noodlot toe. Hij kreeg corona en werd ontzettend ziek. "Op een gegeven moment takelde mijn lichaam steeds verder af. Ik kon niet meer de trap op." Het werd zo erg dat hij nu de hele dag in een half donkere kamer ligt, want prikkels kan hij niet verdragen.

Net als Kelvin lijden steeds meer patiënten die de ziekte postcovid hebben zo erg dat euthanasie de enige uitweg is die ze nog zien. Dit blijkt uit cijfers die EenVandaag heeft opgevraagd bij de Regionale Toetsingscommissies Euthanasie (RTE's). In de jaren van 2022 tot en met 2024 kozen nog negen patiënten voor deze optie, in 2025 lag dit aantal in 1 jaar tijd al op tien.

Al meer dan 2 jaar is Kelvin volledig afhankelijk van de zorg van zijn moeder. We kunnen hem alleen liggend interviewen. Als hij opstaat, dan wordt hij zo duizelig dat hij flauwvalt. Hij kan zich alleen per rolstoel verplaatsen, bijvoorbeeld als hij naar de wc moet.

Voor de rest kan hij alleen maar op bed liggen en soms, op goede dagen, een audioboek luisteren. Kelvin: "Het is één en al verlies. Ik word elke dag weer geconfronteerd met wat ik allemaal niet meer kan. Er is niks meer om naar uit te kijken. Dat voelt eindeloos."

Kelvin heeft het idee dat hij onzichtbaar is geworden voor de maatschappij. "Ik heb het gevoel dat ik levend begraven ben, dat ik ook vergeten ben daardoor. Een soort van verdwenen. Het voelt vaak alsof ik al dood ben, dat ik eigenlijk al niet meer ben. In ieder geval niet de persoon die ik was", omschrijft hij.

Ik heb het gevoel dat ik levend begraven ben, dat ik ook vergeten ben daardoor. Een soort van verdwenen.
Kelvin Latta over zijn postcovid

1 jaar geleden nam hij de loodzware beslissing om een euthanasietraject op te starten. Kelvin: "Ik heb heel veel gesprekken gevoerd met de huisarts, met familieleden en met een geestelijk verzorger. Over hoe ik er zelf in sta. Het is verantwoorden en uitleggen waarom ik mijn leven als uitzichtloos zie. Het is een heel emotioneel traject. Het is de belangrijkste keuze die je kunt maken in je leven. Het is onomkeerbaar."

Jojanneke Kant is huisarts en kent vanuit haar praktijk veel postcovidpatiënten. Ze begrijpt waarom patiënten euthanasie soms als enige uitweg zien. Kant: "Een van mijn patiënten zegt: 'Ik voel me soms gewoon een levende dode.' Het ziektebeeld is zo heftig. Alleen dat kan al genoeg reden zijn voor euthanasie, kan ik me voorstellen als arts."

"Kijk, niemand wil dood. Deze mensen willen niet dood. Alleen ze kunnen niet meer verder met leven. En dat is echt een wezenlijk verschil." Kant snapt dan ook dat patiënten zoals Kelvin hun leven als uitzichtloos ervaren. "Deze mensen zijn al zo lang zo ernstig ziek. Zij zien op een gegeven moment simpelweg geen alternatief meer."

Kant gaat verder: "Als je alleen maar op bed ligt, je niet kunt lezen, je geen film kunt kijken, je met niemand kunt praten. Dan lig je alleen maar op bed te wachten totdat de dag voorbij gaat. Dan heb je geen enkele kwaliteit van leven meer. Die kwaliteit is nul, eigenlijk nog lager dan nul."

De huisarts vindt dat het hier ook een maatschappelijke kwestie gaat. Vanaf 1 januari volgend jaar houdt expertisecentrum C-support op te bestaan, omdat het kabinet de subsidie staakt. Dit heeft grote invloed op patiënten, zegt Kant. "Ik vind dat we deze mensen afschrijven, ik kan het niet anders zeggen. Als je ziet dat expertisecentra de deuren moeten sluiten en hoe weinig langdurig onderzoek er naar de klachten van deze patiënten wordt gedaan, dan snap ik heel erg dat patiënten zich in de steek gelaten voelen. En dat is volgens mij ook zo."

Het steekt Kelvin enorm als er door mensen vraagtekens worden gezet bij de ernst van zijn ziekte."Ik word altijd intens boos als er onbegrip is voor mijn situatie. Mijn hele leven is weggevaagd. Ik was hartstikke actief, ik sportte zes keer per week. Als bewegen de oplossing was, dan had ik dat wel gemerkt."

"Ik heb ook echt alles geprobeerd. Qua medicatie, maar ook fysiotherapie, ergotherapie", somt hij op. "Je ziet misschien niks aan ons van buiten, maar dat betekent niet dat het er niet is. Gelukkig komt er steeds meer bewijs dat er wel degelijk schade aan spieren en het zenuwstelsel te vinden is. Maar dat onbegrip blijft ontzettend pijnlijk."

Begin dit jaar heeft Kelvin zijn euthanasietraject afgerond. Maar toch blijft twijfel een grote rol spelen bij hem. "Er is altijd twijfel. Want wat als ze over een jaar een behandeling vinden of een medicijn dat wel aanslaat? Dan kan mijn leven er weer totaal anders uitzien." Voor Kelvin is het dus vooral een optie voor als het lijden echt niet meer gaat.

Hij heeft weinig hoop op een toekomstige medische doorbraak. "We krijgen amper hulp vanuit de medische wereld. Er wordt geen perspectief geboden vanuit de politiek. Er is te weinig onderzoek. Het lijden is zó intensief en uiteindelijk gaat dat lijden te veel worden. En dat moment wil ik liever voor zijn, dan dat ik daar te laat mee ben."

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sarcozona
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COVID-19 may trigger the same immune pathway as lupus | CIDRAP

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The immune system is the body’s most important defense against disease. It does its essential work by producing proteins called antibodies, which scour the body for disease-causing bacteria, viruses, and other pathogens. 

But sometimes the immune system malfunctions and produces autoantibodies (Abs), proteins that mistakenly target the body’s own tissues instead of finding and destroying illness-causing invaders. This is the case in some COVID-infected people, in whom autoantibodies are linked to severe illness, persistent symptoms, and an increased risk of new-onset autoimmune disease.

This sideways immune response has long been recognized in COVID-19, but what’s been unclear is how this errant process gets set in motion. 

Now, a new study in Immunity sheds light on the immune cells responsible for producing autoantibodies in COVID-infected people and helps explain the molecular process that drives them.

“Our goal was to understand why some people produce autoantibodies after SARS-CoV-2 infection while others do not,” says Jim Heath, PhD, senior author and president of the Institute for Systems Biology (ISB) in Seattle, in an ISB news release. “By combining multiple layers of biological data, we were able to pinpoint the immune cells responsible and identify the regulatory mechanisms that distinguish them.”

DN2 cells overrepresented in high-autoantibody group

For the study, ISB researchers and their partners analyzed data from 209 COVID-infected participants. From this cohort, the researchers selected 12 age-matched women with markedly different autoantibody levels (autoantibody prevalence is higher in women and older adults). 

The team classified the women into two groups—a low-autoantibody group (autoAb-low) and a high-autoantibody group (autoAb-high)—for in-depth analysis. Data were collected before the emergence of the Omicron variant (April 2021) and before participants had been vaccinated.  A separate group of 101 participants was used to validate key results.

According to the findings, a subset of immune cells known as atypical memory B cells were more likely to develop into autoantibody-secreting cells in participants in the autoAb-high group than in those in the autoAb-low group. 

Our findings suggest that SARS-CoV-2 infection can activate an immune program that closely resembles those involved in established autoimmune disorders, helping explain why some individuals experience autoimmune complications following infection.

Plus, the researchers found, a subtype of atypical memory B cells known as double-negative 2 (DN2) B cells were overrepresented in the high-autoantibody group. DN2 cells have been linked to autoantibody production and may play a role in other autoimmune diseases like lupus. 

“A clear difference between autoAb-high and autoAb-low individuals was the enrichment of innate sensing pathways, particularly in DN2s,” write the researchers.

“Our findings suggest that SARS-CoV-2 infection can activate an immune program that closely resembles those involved in established autoimmune disorders, helping explain why some individuals experience autoimmune complications following infection,” lead author Dan Yuan, PhD, of ISB, says in the news release. 

While the current study focused on autoantibody responses following SARS-CoV-2 infection, the findings have broader implications. “Our findings point to specific immune pathways that could become future therapeutic targets," Yuan says in the release. "By understanding how these cells become activated, we move closer to interventions that could prevent or reduce harmful autoimmune responses following infection."

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sarcozona
5 days ago
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Epiphyte City
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