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Nocebo effects with antidepressant clinical drug trial placebos - PubMed

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We describe an individual who experienced unusual negative effects while taking a placebo during a clinical drug trial. A 26-year-old male took 29 inert capsules, believing he was overdosing on an antidepressant. Subsequently, he experienced hypotension requiring intravenous fluids to maintain an adequate blood pressure until the true nature of the capsules was revealed. The adverse symptoms then rapidly abated. The nocebo effect (undesirable symptoms following administration of an inert substance that the patient believes to be an active drug) may have significant negative impacts on certain patients. Further research is warranted to better understand this phenomenon.

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sarcozona
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LeAnn Rimes reveals her struggles with difficult health issue in candid statement about 'heartbreak'

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Jessica Simpson has defended herself after her ex-husband, Nick Lachey, revealed that she flew first class to Hawaii while her three kids sat in coach.

Nick recalled his unexpected run-in with Jessica during a recent appearance on Watch What Happens Live with Andy Cohen, revealing that both their families were on the same flight, marking the first time they had seen each other in 20 years since their divorce.

During the chat, Nick said that Jessica sat in first class, while her children, Maxwell, 14, Ace, 12, and Birdie, seven, flew in a "separate class of service" with their dad, Eric Johnson.

Jessica has now set the record straight, revealing that she had nothing to do with the seating arrangements.

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  1. Newlyweds Turns 20: What have Jessica Simpson and Nick Lachey said about each other?

"My mom bought those tickets. It was my mom's treat for us to go to Hawaii," she said, according to Page Six.

Jessica insisted that if she had bought the tickets, "of course," her children would be seated with her.

Eric Johnson, Jessica Simpson, Birdie Mae Johnson, Ace Knute Johnson and Maxwell Drew Johnson pose at Barnes &amp; Noble Union Square

Nick revealed Jessica sat in first class away from her 3 kids and estranged husband, Eric (Getty Images)

Nick and Jessica were married from 2002 to 2006, and fans saw their marriage deteriorate on their reality show Newlyweds: Nick and Jessica, which ran for two seasons.

Recalling the experience of finding Jessica on the same flight, Nick said it was "strangely okay." He explained: "You know it's been 20 years … and so we haven't seen each other in those 20 years and then spent six and a half hours on a flight to Hawai'i together."

Nick Lachey and Jessica Simpson during Gucci Spring 2006 Fashion Show to Benefit Children&#39;s Action Network and Westside Children&#39;s Center - Arrivals at Home of Eva and Michael Chow in Beverly Hills, California, United States

Jessica and Nick were on the same flight to Hawaii (WireImage)

He then clarified that by "spent" he meant they were simply in the "same vicinity," though emphasized: "Everyone was very very cordial, very respectful."

He further shared that his whole family was on the flight; Nick has been married to Vanessa Lachey since 2011, and they are parents to son Camden, 13, daughter Brooklyn, 11, and son Phoenix, nine.

DAILY POP -- Episode 190429 -- Nick and Vanessa Lachey pose for a photo on set

Nick is now married to Vanessa Lachey (Getty Images)

Jessica, meanwhile, announced her separation from Eric in January 2025 after 10 years of marriage.

The singer, actress, and business mogul confirmed the heartbreaking news in a statement to People, sharing that she and her former NFL player husband had been living apart for some time.

"Eric and I have been living separately, navigating a painful situation in our marriage," Jessica revealed at the time.

Jessica Simpson in white dress and trench and Eric Johnson in blue shirt and red cap

Jessica Simpson and Eric Johnson split in January 2025 (Getty Images)

"Our children come first, and we are focusing on what is best for them. We are grateful for all of the love and support that has been coming our way, and appreciate privacy right now as we work through this as a family."

The former couple has yet to finalize their divorce and appear to be on amicable terms. Last year, after Jessica and Eric spent Thanksgiving together with their kids, the former gave insight into how co-parenting was working for them.

Jessica Simpson poses with Eric Johnson, Birdie Mae Johnson, Ace Knute Johnson and Maxwell Drew on February 05, 2020 in New York City

Jessica and Eric are still on good terms (Getty Images)

Speaking with TMZ at the airport, she said that "of course" they would celebrate the holiday together, maintaining: "It's my kids' father."

It was reported last month that Jessica is dating Nashville-based musician Thomas Eisenhood.

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sarcozona
18 hours ago
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Promising hantavirus vaccine research stalled by funding gap before outbreak

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Promising early results have been put on the back burner despite renewed global concern following a deadly cruise ship outbreak.

Follow us on GoogleMedics work outside of the cruise ship MV Hondius, which was affected by a hantavirus outbreak, after it arrived at the Port of Rotterdam, where Dutch authorities are preparing quarantine arrangements, in Rotterdam, Netherlands, May 18, 2026.Medics work outside of the cruise ship MV Hondius, which was affected by a hantavirus outbreak, after it arrived at the Port of Rotterdam, where Dutch authorities are preparing quarantine arrangements, in Rotterdam, Netherlands, May 18, 2026.(photo credit: YVES HERMAN/REUTERS)ByASHER SMITH

Scientists developing a potential vaccine for hantavirus halted key research efforts after running out of funding during trials in 2016, despite promising early results and amid renewed global concern following a deadly outbreak linked to a cruise ship in South America, according to a recent Bloomberg report.

The report came in the wake of increased attention on hantavirus after the World Health Organization (WHO) confirmed multiple infections and at least three deaths connected to an outbreak involving the Andes strain of the virus aboard the MV Hondius cruise ship, which left Argentina on April 1. 

Unlike most hantaviruses, which spread through contact with infected rodents, the Andes variant can spread from person to person, raising concerns among infectious disease experts about broader transmission risks, according to the WHO.

María Inés Barría, a virologist and researcher at Universidad San Sebastián in Chile, developed antibodies to treat hantavirus and successfully neutralized it in 2016.

After successful animal testing, the lab was ready to begin testing on human subjects when they ran out of money and had to end their research prematurely.

The body of a German woman who died is disembarked from the cruise ship MV Hondius, which was affected by a hantavirus outbreak, after the ship arrived at the Port of Rotterdam, where Dutch authorities are preparing quarantine arrangements, in Rotterdam, Netherlands, May 18, 2026.The body of a German woman who died is disembarked from the cruise ship MV Hondius, which was affected by a hantavirus outbreak, after the ship arrived at the Port of Rotterdam, where Dutch authorities are preparing quarantine arrangements, in Rotterdam, Netherlands, May 18, 2026. (credit: PIROSCHKA VAN DE WOUW/REUTERS)

Hantavirus outbreak renews global interest in combating the virus

Global attention has peaked with the discovery of an outbreak of the Andes strain of hantavirus on a cruise ship, and the need for vaccines and effective antibodies has risen.

Kartik Chandran, a professor at the Albert Einstein College of Medicine, has been incrementally developing a vaccine and an antibody treatment. The research Chandran is conducting on the virus is in its early stages, but results have shown effectiveness in protecting against the Andes strain in early trials.

Chandran told Bloomberg that the results indicate they are ready to move on to testing in humans.

“We are engaged in a number of conversations with various parties,” he said. “The goal would be to have something available should there be another outbreak. I’m optimistic that we’ll learn from the current situation and be positioned for hantaviruses down the road.”

However, with so few cases of hantavirus, conducting clinical trials in humans would be difficult for researchers, Chandran told Bloomberg

The race to develop vaccines

The race to develop a vaccine is more intense back in Chile, where there have been 39 confirmed infections and at least 13 deaths, according to the Chilean Health Ministry.

The source of the outbreak on the MV Hondius cruise ship that departed from Argentina remains a mystery. However, before headlines began reporting on the viral outbreak aboard a cruise ship, Chile was already laying the groundwork to develop a vaccine, but funding dried up, and the global COVID-19 crisis diverted resources.

The virus had gone largely overlooked outside southern Chile in part because it is rare and geographically concentrated, Barría said. “It has always been a public health problem here, but without a solution,” she added.

As the outbreak on the cruise ship draws global attention, the race to develop a vaccine has been restarted, but Barría has said the researchers need funding and time.

“The key factor that’s preventing further progress is funding and resources,” she told Bloomberg.

“We have made significant advances, but we’ve reached a stage that is much more expensive and requires a different level of investment, as well as specific infrastructure that we are currently lacking.”

On top of the need for funding, Barría also estimated that her team at Universidad San Sebastián in Chile would need one to two years to return to the place they were before the Covid-19 pandemic and funding troubles interrupted their research.

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sarcozona
18 hours ago
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WHO delays pandemic treaty amid pathogen-sharing dispute | Reuters

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sarcozona
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U of C student living with POTS leads new study on long-term impacts of chronic condition | CBC News

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A Calgary student is drawing from lived experience with a neurological disorder to further the medical field's understanding of it.

University of Calgary medical student Kate Bourne is the lead author of a new study on long-term care outcomes of patients with postural orthostatic tachycardia syndrome (POTS), a chronic condition she was diagnosed with at 24.

POTS, a disorder of the nervous system that primarily affects women of childbearing age, causes symptoms such as rapid heartbeat, dizziness, fatigue and nausea when standing up.

The study, which involved 44 patients diagnosed over 20 years ago, suggests that while POTS did not disappear in the vast majority of long-term patients, almost half had their symptoms improve through treatment, time or a combination of both.

The University of Calgary estimates the condition affects up to 450,000 Canadians.

University of Calgary student and study lead author Kate Bourne was diagnosed with postural orthostatic tachycardia syndrome at 24, after first displaying symptoms over a decade beforehand. Now, at 36 years old, Bourne is looking to dedicate her career as a doctor and researcher to studying the condition. (Kristen Fong/Cumming School of Medicine)

POTS is a subject Bourne is all too familiar with.

"It actually took me 12 years to get a diagnosis of POTS," said Bourne.

She says she first became sick at 12 years old, experiencing gastrointestinal symptoms and fatigue that doctors struggled to explain.

"I was a very active child," she said. "I played lots of sports, horseback riding, music, and then all of a sudden I couldn't get out of bed."

The persistent unexplained symptoms forced her to do an extra year of high school and take eight years to complete her undergraduate degree, she said.

Now, at 36 years old, Bourne's symptoms are well controlled with available treatments. While she still has bad days, she's got a good hold on managing her condition.

"My career goal is actually to be a doctor and researcher studying POTS, so that hopefully other young women and girls don't have to experience the challenges that I've experienced," she said.

Rashmin Hira, left, takes part in research with Kate Bourne. (Kristen Fong/Cumming School of Medicine)

"It definitely helps me relate to research participants," Bourne said on being a POTS patient herself.

"Oftentimes they'll tell me that I'm the first person they've ever met who has POTS, and that helps to build the relationship in the research setting."

Study lead Dr. Satish Raj, a professor with the university's department of cardiac sciences, said the new findings offer a better understanding of the long-term outcomes for POTS patients.

"For most patients, it doesn't go away," he said. "Only two per cent of the patients reported that the symptoms totally resolved. That's the bad news. The good news is that for almost half the patients, they report that over time their symptoms improved."

Raj said this offers hope that interventions can lead to better functioning, even if not a complete return to normalcy.

"I think this is important news for patients, but also for physicians to say this is actually something that is serious and we're going to need to treat," Raj said.

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The Many Casualties of Precision Warfare

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Since September 11, 2001, the United States has launched or led military operations across at least eighty-five countries. Up to 4.7 million people have died as a direct or indirect result of these post-9/11 wars, according to Brown University’s Costs of War Project. Thirty-eight million have been displaced, at a financial cost exceeding $8 trillion.

The 2003 US invasion of Iraq — launched on the false premise of weapons of mass destruction — dismantled the Iraqi state, dissolved its military, and ignited a sectarian civil war carrying decades-long consequences, among them the rise of the Islamic State. By mid-2014, ISIS had seized large swaths of Iraq and Syria, declaring a caliphate across a territory roughly the size of Jordan.

The bombs were Dutch. The intelligence was American. The dead were Iraqi — and no one has been held responsible.

The United States assembled a coalition of at least eighty nations — Operation Inherent Resolve — to destroy the so-called caliphate from the air, directing operations from thousands of miles away through allied jets, classified intelligence, and computer-generated damage estimates.

Hawija, a traditionally Sunni town, fell to ISIS in June 2014 and remained under its control until October 2017. The coalition’s target — an ISIS facility assembling vehicle-borne improvised explosive devices — had been monitored from Virginia since December 2014. It sat in what planners called an “industrial zone.” In Iraq, this is not a depopulated business park but mixed-use: people live above workshops, homes share walls with shops, and government buildings sit beside small factories.

“There was a baseline lack of understanding of local context,” says Emily Tripp, director of Airwars, an investigative organization tracking civilian harm from air and drone strikes. “They just assumed civilians weren’t there.”

A white truck is parked in front of a one-story building with bullet holes and visible damage.Buildings across Hawija remain pockmarked by the violence of years of war, as the town fell under ISIS control in June 2014 and remained so until October 2017. (Jaclynn Ashly / Jacobin)

A Dutch commission of inquiry last year found the coalition should have known civilians were present — the International Organization for Migration (IOM) had publicly documented the influx of displaced people into Hawija’s industrial zone as early as February 2015.

Targeting was US-led and intelligence was US-controlled, running through the coalition’s operations center in Qatar. US agencies vetted the target, identified as sitting in an urban industrial zone surrounded by residential areas. The Central Intelligence Agency (CIA) specifically flagged the proximity of one. The strike was initially rated CDE-5 High, the “Collateral Damage Estimation” indicating expected civilian casualties, so planners revised the loadout to lighter Small Diameter Bombs, lowering it to CDE-5 Low.

But the model excluded secondary explosions, as the stored quantity was unknown. All US agencies — including the CIA — approved the strike, and the CIA’s flag about the residential neighborhood was never passed to the Dutch pilots or authorizing officers.

The Netherlands drew the strike as the only coalition member other than the United States with Small Diameter Bombs. Dutch Red Card Holders — national officials with veto power — saw that the target sat in a populated area with residential blocks nearby, as well as a mosque. Unable to independently verify US intelligence, they pushed the strike from 9 p.m. to midnight, betting fewer civilians would be outside.

A cream-colored building with a significant number of bullet holes on its exterior.Bullet-scarred walls stand as reminders of the layered conflicts that have shaped Hawija, where residents endured both ISIS rule and the coalition air campaign waged to dislodge it. (Jaclynn Ashly / Jacobin)

Just after midnight, two Dutch F-16s released their bombs. A massive secondary explosion followed — unlike anything seen in a coalition strike. Civilian casualties were immediately assumed, yet the Dutch Ministry of Defence told Parliament there were no indications of civilian harm — a position it maintained for years despite internal intelligence to the contrary. Dutch military intelligence later estimated fifty thousand to one hundred thousand kilograms of explosives at the site — up to five times the United States’s initial post-strike estimate.

Driving through Hawija today, the scars remain — pockmarked walls, empty lots, rubble strewn across the ground. Seated on the floor of his still window-shattered home, his small children around him, Khaled Ahmad, forty-seven, recounts what happened.

A man sits on the floor raising his arm and pointing upward while two small boys sit on either side of him.Khaled Ahmad sits on the floor of his still window-shattered home in Hawija with his sons, recounting the night of June 2, 2015, when shrapnel killed his twenty-year-old brother within minutes and wounded his mother, who died of stomach cancer a month later. (Jaclynn Ashly / Jacobin)

He had been sleeping on the roof with his family. Windows shattered, doors blew inward, and part of the house collapsed. His wife’s legs were cut by flying glass. His youngest son suffered a head injury. Shrapnel tore through his twenty-year-old brother, killing him within minutes. His sixty-year-old mother was also wounded; weeks later, she developed stomach cancer and died a month after.

A man stands in a room next to a curtained window, leaning over and pointing outside. Khaled Ahmad shows the windows of his home in Hawija, still shattered more than a decade after the 2015 blast that destroyed his car-electrical shop — his only source of income — a kilometer away. (Jaclynn Ashly / Jacobin)A man stands in an alley next to a large beige-colored metal door with green graffiti on it.Khaled Ahmad stands outside the empty plot where his car-electrical shop once stood a kilometer from the blast site — destroyed in the 2015 strike and never rebuilt. (Jaclynn Ashly / Jacobin)

Ahmad’s car-electrical shop — his only income, a kilometer from the blast — was destroyed. It remains that way. “My mother was the beating heart of our family, and I think about my brother every single day,” he says. “Families in Hawija are still broken by this.”

What followed was not rescue but chaos under ISIS control. The group ran the hospitals and controlled movement.

“Using explosive weapons in urban areas under insurgent control creates an extremely difficult situation for civilians,” says Lauren Gould, associate professor in conflict studies at Utrecht University. “There are no troops on the ground to secure access to care. ISIS made medical access political — people with severe injuries were turned away.”

Others pledged allegiance for treatment. Some were stitched by pharmacists without anesthesia. Those who could afford smugglers navigated checkpoints and mined roads to hospitals in Mosul, Kirkuk, or Baghdad. Treatable injuries became permanent.

In a sunlit sitting room across town, Hussein Ibrahim Hussein, fifty-six, edges forward. He lived five hundred meters from the blast. “Our home was completely destroyed,” he recalls. Many neighbors were displaced families hoping to reach Kurdish-controlled Kirkuk city. “Their bodies were scattered across the streets.”

A young man sits in the foreground with an injured eye while an older man sits behind him. Hussein Ibrahim Hussein with his son, now twenty-two, who was blinded in his right eye by a fifteen-centimeter shard of glass from the 2015 blast and says, “I feel like they stole my future from me.” (Jaclynn Ashly / Jacobin)

His brother was found dead on the road, thrown from the house. His son’s face was covered in blood — a fifteen-centimeter shard of glass lodged in his right eye. Overwhelmed doctors could offer only first aid, so Hussein smuggled his son out. “I sold all my wife’s gold — everything,” he says.

After fleeing to Turkey and Iran and five years seeking treatment, every diagnosis was the same: irreversible retinal detachment and permanent blindness. His son, Hussein Ibrahim, now twenty-two, suffers balance problems and headaches that leave him unable to work. “I feel like they stole my future from me,” he says, eyes fixed on the floor.

Like many victims of coalition airstrikes, Hawija’s residents did not know whose planes struck them. Only when Dutch media reported on the strike in 2019 did the community learn the bombs had been Dutch.

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sarcozona
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